Population
Human umbilical vein endothelial cells (HUVEC) and aspirin-treated platelets
Comparison
Stimulation with thrombin, IL-1alpha, phorbol… vs Untreated cells or cells without specific…
Design
Preclinical
Follow-up
up to >18 hours (in vitro)
Authors
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Suggests Cox compartmentalization may alter endothelial prostanoid balance after aspirin; hypothesis-generating and requires in vivo confirmation before clinical relevance.
Short-term activation of endothelial cells leads to Cox compartmentalization that selectively affects transcellular thromboxane metabolism.
Karim et al. (1996) studied this question.
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