April 16, 2012PLoS ONEOpen Access

Deep RNA Sequencing Reveals Novel Cardiac Transcriptomic Signatures for Physiological and Pathological Hypertrophy

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Population

Models of physiological hypertrophy (PHH) and pathological hypertrophy (PAH) of the heart

Comparison

RNA sequencing (RNA-Seq) vs Normal heart and comparison between PHH and PAH

Design

Preclinical

Authors

HSHong Ki SongKangdong Sacred Heart Hospital SHSeong‐Eui HongTheragen TKTae-Yong KimSeoul National University

Discussion

Member takes

Implication

Suggests molecular distinctions in hypertrophy subtypes in animals; leaves open human translation and therapeutic targeting.

Structured PICO

Population

Models of physiological hypertrophy (PHH) and pathological hypertrophy (PAH) of the heart

Intervention

RNA sequencing (RNA-Seq)

Comparator

Normal heart and comparison between PHH and PAH

Outcome

Transcriptomic signatures including differentially expressed genes (DEGs) and alternative splicing (AS) patternssurrogate

Deep RNA sequencing reveals distinct quantitative and qualitative transcriptomic signatures, including specific hub proteins and alternative splicing events, that differentiate pathological from physiological cardiac hypertrophy.

Cite This Study

Song et al. (2012) studied this question.

synapsesocial.com/papers/6a6faefd5d37378ac1dcbd67 https://doi.org/10.1371/journal.pone.0035552

Topics

Heart failure HFrEF treatment

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Deep RNA Sequencing Reveals Novel Cardiac Transcriptomic Signatures for Physiological and Pathological Hypertrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Deep RNA Sequencing Reveals Novel Cardiac Transcriptomic Signatures for Physiological and Pathological Hypertrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider