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May 26, 2005Journal of Virology

Proteolytic Processing of Sapovirus ORF1 Polyprotein

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Population

In vitro coupled transcription-translation system expressing full-length and truncated forms of Sapovirus…

Comparison

Mutagenesis in the 3C-like protease motif vs Wild-type ORF1 polyprotein

Design

Preclinical

Authors

OTOka TSutter HealthKKKazuhiko KatayamaHiroshima UniversitySOSatoko OgawaNational Agriculture and Food Research Organization

Discussion

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Implication

Maps Sapovirus polyprotein processing and protease dependence; leaves open antiviral targeting pending further validation.

Structured PICO

P
Population
In vitro coupled transcription-translation system expressing full-length and truncated forms of Sapovirus (SaV) ORF1 polyprotein (strain Mc10)
I
Intervention
Mutagenesis in the 3C-like protease motif (1171Cys to Ala of the GDCG motif)
C
Comparator
Wild-type ORF1 polyprotein
O
Outcome
Proteolytic cleavage of the ORF1 polyproteinsurrogate

The study maps the proteolytic cleavage of the Sapovirus ORF1 polyprotein and demonstrates that the virus-encoded 3C-like protease is essential for this processing.

Cite This Study

T et al. (2005) studied this question.

synapsesocial.com/papers/6a6faf2a5d37378ac1dcbdbahttps://doi.org/10.1128/jvi.79.12.7283-7290.2005
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