Identification of the cleavage sites of sapovirus open reading frame 1 polyprotein

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Population

Sapovirus (SaV) open reading frame 1 (ORF1) polyprotein (human GII SaV Mc10 strain)

Design

Preclinical

Authors

Discussion

May inform sapovirus antiviral design; leaves open human relevance and requires prospective validation.

Population

Sapovirus (SaV) open reading frame 1 (ORF1) polyprotein (human GII SaV Mc10 strain)

Intervention

In vitro coupled transcription-translation, SDS-PAGE, immunoprecipitation, and N-terminal amino acid sequencing

Outcome

Identification of cleavage sites in the ORF1 polyprotein

The study identified six specific cleavage sites in the sapovirus ORF1 polyprotein, revealing conserved dipeptides at these sites across genogroups.

T et al. (2006) studied this question.

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