Why the study?
Does supranormal coronary blood flow induced by adenosine increase myocardial oxygen consumption, high energy phosphate levels, and systolic function in the in situ autoperfused porcine heart?
Population
13 anaesthetised open chest pigs with an intact, autoperfused coronary circulation, weight 30-40 kg
Comparison
Regional hyperperfusion of the anterior left… vs Basal conditions
Design
Preclinical
Authors
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Supranormal coronary flow does not augment MVO2 or systolic function in normal porcine hearts; leaves open whether flow limits metabolism in human disease.
Does supranormal coronary blood flow induced by adenosine increase myocardial oxygen consumption, high energy phosphate levels, and systolic function in the in situ autoperfused porcine heart?
Supranormal coronary blood flow does not augment myocardial oxygen consumption or systolic function, suggesting oxygen delivery does not limit oxidative metabolism under normal conditions.
Schwartz et al. (1992) studied this question.
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