Why the study?
Do children with new-onset juvenile dermatomyositis have increased prior symptoms, environmental exposures, familial autoimmune diseases, or specific antibody titers compared to healthy children or those with JRA?
Do children with new-onset juvenile dermatomyositis have increased prior symptoms, environmental exposures, familial autoimmune diseases, or specific antibody titers compared to healthy children or those with JRA?
Children with new-onset juvenile dermatomyositis frequently experience constitutional symptoms 3 months prior to disease onset, but do not show increased frequencies of familial autoimmune disease or specific viral/parasitic antibody titers compared to controls.
No takes yet. Share an insight, caveat, or question.
Constitutional symptoms may precede juvenile DM onset; case-control data leave roles of familial autoimmunity and specific infections open.
Pachman et al. (1997) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: