April 7, 2005Arthritis Care & ResearchOpen Access

History of infection before the onset of juvenile dermatomyositis: Results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Research Registry

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Juvenile dermatomyositis (JDM) (n=286). Intervention: History of infection (respiratory or gastrointestinal complaints). Primary outcome: Presence of respiratory or gastrointestinal complaints in the 3 months before disease onset.

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Key result

A history of respiratory complaints (57%) or gastrointestinal symptoms (30%) was frequently reported in the 3 months prior to the onset of juvenile dermatomyositis.

Population

286 children within 6 months of juvenile dermatomyositis diagnosis, predominantly white, girl:boy ratio 2:1…

Design

Cohort

Authors

LPLauren M. PachmanNorthwestern University RLRebecca B. LiptonNorthwestern University RRRosalind Ramsey‐GoldmanNorthwestern University

Discussion

Member takes

Implication

Should not change practice; hypothesis-generating for infectious triggers in juvenile dermatomyositis pending prospective studies.

Study Design

Type

Observational (n=286)

Multicenter

Yes

Structured PICO

Population

286 children within 6 months of juvenile dermatomyositis diagnosis evaluated for a history of infection in the 3 months prior to disease onset.

Outcome

Frequency of respiratory or gastrointestinal symptoms in the 3 months before JDM onset

A significant proportion of children with juvenile dermatomyositis have a history of respiratory or gastrointestinal infections in the 3 months preceding disease onset, suggesting a potential infectious trigger in pathogenesis.

Cite This Study

Pachman et al. (2005) conducted an observational in Juvenile dermatomyositis (JDM) (n=286). History of infection (respiratory or gastrointestinal complaints) was evaluated on Presence of respiratory or gastrointestinal complaints in the 3 months before disease onset. A history of respiratory complaints (57%) or gastrointestinal symptoms (30%) was frequently reported in the 3 months prior to the onset of juvenile dermatomyositis.

synapsesocial.com/papers/6a70788dc1a24a6142db84fa https://doi.org/10.1002/art.21068

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History of infection before the onset of juvenile dermatomyositis: Results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Research Registry

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

History of infection before the onset of juvenile dermatomyositis: Results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Research Registry

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider