Why the study?
Does quinaprilat or losartan improve the NO/O2(-) balance in human aortic endothelial cells exposed to pulsatile stretch?
Does quinaprilat or losartan improve the NO/O2(-) balance in human aortic endothelial cells exposed to pulsatile stretch?
ACE inhibition and AT1 receptor antagonism restore endothelial NO/O2(-) balance under pulsatile stretch, providing a molecular mechanism for their vascular protective effects.
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Provides mechanistic insight from animal models; leaves open applicability to human aortic endothelial cells under pulsatile stretch.
Mechanical forces and the activation of the renin-angiotensin system (RAS) may alter the NO/O2(*-) balance, imparing endothelial nitric oxide (NO) availability. This study investigates the link between RAS and NO/O2(*-) balance in human aortic endothelial cells (HAEC) exposed to pulsatile stretch with and without ACE inhibitor quinaprilat or angiotensin II type 1 (AT(1)) receptor antagonist losartan. Pulsatile stretch increased Ang II levels and O2(*-) production, reducing NO release. RAS blockade with quinaprilat or losartan restored the balance between NO and O2(*-). These results provide a molecular basis for understanding the vascular protective effects of ACE inhibition and AT(1) receptor antagonism.
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Gatti et al. (2008) studied this question.
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