Why the study?
A better understanding of the genetic, epigenetic, hemodynamic, lipid metabolism, and inflammatory mechanisms in atherogenesis may improve patient diagnosis and management.
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Design
Review
Gene therapy for atherosclerosis remains hypothesis-generating; larger trials needed before clinical consideration.
Atherosclerosis is one of the most important medical problems due to its prevalence and significant contribution to the structure of temporary and permanent disability and mortality. Atherosclerosis is a complex chain of events occurring in the vascular wall over many years. Disorders of lipid metabolism, inflammation, and impaired hemodynamics are important mechanisms of atherogenesis. A growing body of evidence strengthens the understanding of the role of genetic and epigenetic factors in individual predisposition and development of atherosclerosis and its clinical outcomes. In addition, hemodynamic changes, lipid metabolism abnormalities, and inflammation are closely related and have many overlapping links in regulation. A better study of these mechanisms may improve the quality of diagnosis and management of such patients.
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Stanislav Kotlyarov (2023) studied this question.
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