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March 19, 2003Proceedings of the National Academy of SciencesOpen Access

Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism

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Why the study?

Does the Ile/Val variant in the d-AKAP2 gene affect PR interval and PKA-RIalpha binding in healthy individuals?

Population

Age-stratified healthy European-American individuals and an independent sample for electrocardiogram analysis.

Comparison

Val variant of the Ile/Val single-nucleotide… vs Ile variant of the d-AKAP2 gene.

Design

Cross-sectional

Authors

SKStefan KammererGriffith UniversityLHLora HamuroMerck & Co., Inc., Rahway, NJ, USA (United States)YMYuliang MaBeijing Institute of Technology

Discussion

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Overview

Val variant linked to shorter PR interval; hypothesis-generating for conduction effects in aging, warranting prospective validation.

Structured PICO

Does the Ile/Val variant in the d-AKAP2 gene affect PR interval and PKA-RIalpha binding in healthy individuals?

P
Population
Age-stratified healthy European-American individuals (DNA pools) and an independent sample for electrocardiogram analysis.
I
Intervention
Val variant of the Ile/Val single-nucleotide polymorphism in the dual-specific A kinase-anchoring protein 2 (d-AKAP2) gene.
C
Comparator
Ile variant of the d-AKAP2 gene.
O
Outcome
Correlation of allele frequency with age and length of the electrocardiogram PR interval.surrogate

The Ile/Val polymorphism in the d-AKAP2 gene alters PKA-RIalpha binding and subcellular localization, which is associated with decreased PR interval and may impact cardiac function in aging populations.

Cite This Study

Kammerer et al. (2003) studied this question.

synapsesocial.com/papers/6a6fb02c6ceb2bbd16dfb5dehttps://doi.org/10.1073/pnas.2628028100
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