Highlights the significant diversity and fluctuation of rotavirus strains in West Africa, which is important for regional vaccine development and deployment.
Rotavirus strain diversity and fluctuation in West Africa may affect vaccine performance; leaves open optimal regional vaccine selection.
followed by G3 (19.5%), G2 (13.6%), and G9 (10.3%). The common G-P combinations were G1P[6] (11.2%), G2P[6] (9.8%) and G9P[8] (8.0%). Considerable G type fluctuation was detected from year to year in the subregion, as well as country-specific variation in circulating strains over time. Rotavirus G9 strains were detected with increasing frequency across the region, but rotavirus G4 strains were seen only in Cameroon, and strains with P[4] specificities were relatively rare, except in Ghana and Cameroon. Strains carrying unusual G-P combinations, such as G2P[6], G3P[6], and G9P[6], were also common.
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Armah et al. (2010) studied this question.
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