November 1, 1995Microbiology and ImmunologyOpen Access

Genetic Variation in VP7 Gene of Human Rotavirus Serotype 2 (G2 Type) Isolated in Japan, China, and Pakistan

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Population

16 human isolates of serotype 2 of rotavirus

Comparison

Sequence analysis of the gene encoding the major… vs HU5 strain

Design

Preclinical

Authors

LWLe-ying WenChinese Center For Disease Control and Prevention HUHiroshi UshijimaNihon University JKJunko KakizawaNational Center for Global Health and Medicine

Discussion

Member takes

Implication

Rotavirus epitope variations support subtype classification; leaves open relevance to neutralizing immunity or vaccines.

Structured PICO

Population

16 human isolates of serotype 2 of rotavirus

Intervention

Sequence analysis of the gene encoding the major neutralization glycoprotein (VP7)

Comparator

HU5 strain

Outcome

Nucleotide and deduced amino acid sequences homology and variations

Sequence analysis of human rotavirus serotype 2 isolates suggests classification into three subtypes based on amino acid sequences in the major neutralizing epitope regions.

Cite This Study

Wen et al. (1995) studied this question.

synapsesocial.com/papers/6a6fb30f8031ec7bb1dbe599 https://doi.org/10.1111/j.1348-0421.1995.tb03277.x

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Genetic Variation in VP7 Gene of Human Rotavirus Serotype 2 (G2 Type) Isolated in Japan, China, and Pakistan

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genetic Variation in VP7 Gene of Human Rotavirus Serotype 2 (G2 Type) Isolated in Japan, China, and Pakistan

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider