January 1, 1998DNA sequence

Sequence Comparison of the VP7 of Serotype G2 Rotaviruses from Diverse Geographical Locations

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Population

Twelve serotype G2 rotavirus isolates from Australia and published sequences from strains collected…

Comparison

Sequence comparison and phylogenetic analysis of… vs Strain DS1

Design

Preclinical

Authors

Discussion

May limit DS1 vaccine coverage regionally; leaves open need for updated antigens in future rotavirus trials.

Population

Twelve serotype G2 rotavirus isolates from Australia and published sequences from strains collected worldwide between 1976 and 1993

Intervention

Sequence comparison and phylogenetic analysis of the VP7 gene

Comparator

Strain DS1 (included in the rhesus rotavirus tetravalent vaccine formulation)

Outcome

Geographical clustering and phylogenetic relationship to strain DS1surrogate

Most serotype G2 rotavirus strains are distantly related to the DS1 vaccine strain, which has implications for future vaccine strategies.

Piec et al. (1998) studied this question.

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