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October 1, 1994Journal of Medical Virology

Serotyping of human rotaviruses in the Tokyo area (1990–1993) by enzyme immununoassay with monoclonal antibodies and by reverse transcription and polymerase chain reaction amplification

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Population

Human rotavirus strains in the Tokyo area (1990-1993)

Design

Other

Authors

HUHiroshi UshijimaAMAtsushi MukoyamaAHAyako Hasegawa

Discussion

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Overview

Supports EIA-MAbs as alternative for rotavirus serotyping; leaves open impact of intraserotypic variations on vaccines.

Structured PICO

P
Population
Human rotavirus strains in the Tokyo area (1990-1993)
I
Intervention
Serotyping by enzyme immunoassay with monoclonal antibodies (EIA-MAbs) against VP7 and by reverse transcription and polymerase chain reaction (RT-PCR) amplification of the VP4 and VP7 genes
O
Outcome
Serotype identification and comparison of EIA-MAbs and RT-PCR results

EIA-MAbs and RT-PCR provide similar results for rotavirus serotyping, highlighting intraserotypic variations relevant for vaccine development.

Cite This Study

Ushijima et al. (1994) studied this question.

synapsesocial.com/papers/6a6fb30f8031ec7bb1dbe59chttps://doi.org/10.1002/jmv.1890440208
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection and serotyping of rotaviruses in stool specimens by using reverse transcription and polymerase chain reaction amplification1992 · 58 citations
  2. 2Typing of human rotavirus VP4 by an enzyme immunoassay using monoclonal antibodies1993 · 63 citations
  3. 3Occurrence of changes in human rotavirus serotypes with concurrent changes in genomic RNA electropherotypes1988 · 93 citations
  4. 4Polymerase chain reaction amplification and typing of rotavirus nucleic acid from stool specimens1990 · 1,581 citations
  5. 5Identification of group A rotavirus gene 4 types by polymerase chain reaction1992 · 1,408 citations