What question did this study set out to answer?

To characterize the frequency, clinical types, and underlying pathophysiological mechanisms of paroxysmal attacks occurring in multiple sclerosis.

January 1, 1975Brain

Paroxysmal Attacks in Multiple Sclerosis

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Authors

POP. O. OstermanUppsala University CWC-E. WESTERBERGUppsala University Hospital

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Implication

Clinical cohort study reveals paroxysmal attacks in multiple sclerosis, suggesting ephaptic axonal transmission across demyelinated central nervous system lesions.

Key Points

To characterize the frequency, clinical types, and underlying pathophysiological mechanisms of paroxysmal attacks occurring in multiple sclerosis.
Retrospective clinical evaluation of 235 patients with confirmed or suspected multiple sclerosis treated over an 8-year period (1966–1973) at a neurological clinic in Uppsala.
Phenotypic classification of paroxysmal attack presentations alongside an illustrative comparative case of tonic seizures following traumatic cervical spinal cord injury.
Paroxysmal attacks occurred in 22 of 235 patients (9.4%), with paroxysmal dysarthria and ataxia (7 cases) and tonic seizures (5 cases) being the most prevalent presentations.
Identified novel paroxysmal presentations including paroxysmal hemiataxia with crossed paresthesias, isolated diplopia, and paroxysmal itching, all consistent with laterally spreading ephaptic cross-activation across partially demyelinated central axons.

Cite This Study

Osterman et al. (1975) studied this question.

synapsesocial.com/papers/6a6fb34fe71d69abee082a7c https://doi.org/10.1093/brain/98.2.189

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Implication

Clinical cohort study reveals paroxysmal attacks in multiple sclerosis, suggesting ephaptic axonal transmission across demyelinated central nervous system lesions.

Paroxysmal Attacks in Multiple Sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Paroxysmal Attacks in Multiple Sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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