Why the study?
Does increased temperature cause conduction block in experimentally demyelinated rat ventral root fibers?
Population
Experimentally demyelinated rat ventral root fibers
Comparison
Increases of temperature of 0.5 C within the… vs Baseline temperature / normal internodes
Design
Preclinical
Authors
Loading...
Provides mechanistic basis for MS temperature sensitivity; leaves open translation from rat model to patients.
Does increased temperature cause conduction block in experimentally demyelinated rat ventral root fibers?
Small increases in temperature cause reversible conduction block in demyelinated nerve fibers, providing a physiological explanation for temperature sensitivity in multiple sclerosis.
Michael Rasminsky (1973) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: