Population
Gnotobiotic BALB/c, CD-1, and CFW mice and conventional BALB/c mice
Comparison
Parenteral immunization with the Wa, SA-11, or… vs Unimmunized state (baseline sera)
Design
Preclinical
Authors
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Supports mouse model for heterologous rotavirus immunity studies; leaves open human translation.
The mouse can serve as a useful model for studying the immune response to heterologous rotavirus infection, as preexisting murine rotavirus antibodies do not prevent type-specific immune responses to nonmurine rotaviruses.
Offit et al. (1983) studied this question.
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