Population
143 culture-adapted human rotavirus isolates collected in Bangladesh during 1985 to 1986
Comparison
Serotyping by enzyme-linked immunosorbent assay… vs Neutralization with serotype-specific…
Design
Preclinical
Authors
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Monoclonal ELISA supports specific serotyping in animal models; leaves open whether multi-epitope panels can improve sensitivity for diagnostics.
Epitope variations between rotavirus strains cause significant differences in monoclonal antibody sensitivity, suggesting that using multiple monoclonal antibodies directed at different epitopes may improve serotyping sensitivity.
Ward et al. (1991) studied this question.
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