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April 1, 1992Journal of Clinical MicrobiologyOpen Access

Distribution of serotypes of human rotavirus in different populations

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Key result

Enzyme immunoassay serotyping of 1,183 rotavirus-positive specimens revealed serotype 1 as the most prevalent (48%), followed by serotypes 3 (15%), 2 (8%), and 4 (7%).

Why the study?

What is the distribution of human rotavirus serotypes in different populations?

Population

1,183 rotavirus-positive specimens from 16 stool collections in eight countries on four continents obtained…

Design

Cross-sectional

Authors

PWPatricia WoodsVA Boston Healthcare SystemJGJ. GentschCenters for Disease Control and PreventionVGVera GouvêaUniversidade Federal do Rio de Janeiro

Discussion

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Implication

Supports serotype 1 focus in rotavirus vaccine design; leaves open regional applicability pending broader surveillance.

Study Design

Type

Observational (n=1,183)

Multicenter

Yes

Structured PICO

What is the distribution of human rotavirus serotypes in different populations?

P
Population
1,183 rotavirus-positive specimens from 16 stool collections in eight countries on four continents obtained from 1978 to 1989
I
Intervention
Serotyping using an enzyme immunoassay with serotype-specific monoclonal antibodies
O
Outcome
Distribution of rotavirus serotypes

Serotype 1 is the most common rotavirus serotype globally, indicating that vaccines in development must provide the greatest coverage against it.

Limitations

  • Twenty-two percent of specimens had insufficient numbers of double-shelled virus particles to react with the monoclonal antibody and could not be serotyped.
  • 22% of specimens had insufficient numbers of double-shelled virus particles to react with the monoclonal antibody and could not be serotyped

Cite This Study

Woods et al. (1992) conducted an observational in Rotavirus infection (n=1,183). Enzyme immunoassay serotyping was evaluated on Distribution of rotavirus serotypes. Enzyme immunoassay serotyping of 1,183 rotavirus-positive specimens revealed serotype 1 as the most prevalent (48%), followed by serotypes 3 (15%), 2 (8%), and 4 (7%).

synapsesocial.com/papers/6a0aa40f0633f37a5370a834https://doi.org/10.1128/jcm.30.4.781-785.1992
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subgroups, serotypes, and electrophoretypes of rotavirus isolated from children in Bangui, Central African Republic1988 · 63 citations
  2. 2Reactivities of serotyping monoclonal antibodies with culture-adapted human rotaviruses1991 · 52 citations
  3. 3Serotypes and Electropherotypes of Human Rotavirus in the USA: 1987-19891990 · 81 citations
  4. 4Diversity of rotavirus serotypes in Mexican infants with gastroenteritis1990 · 70 citations
  5. 5Relative frequencies of rotavirus serotypes 1, 2, 3, and 4 in Venezuelan infants with gastroenteritis1988 · 61 citations