Why the study?
Does inoculation with bovine, foal, or human rotaviruses protect gnotobiotic calves against pathogenic bovine rotavirus challenge?
Does inoculation with bovine, foal, or human rotaviruses protect gnotobiotic calves against pathogenic bovine rotavirus challenge?
Live attenuated bovine rotavirus induces homologous protection in calves if given sufficient time (7-21 days), whereas heterologous rotaviruses (foal, human) offer limited cross-protection.
May inform timing of homologous rotavirus vaccines in calves; leaves open heterologous cross-protection and translation beyond this model.
Inoculation at birth with a live attenuated strain of a bovine rotavirus isolated in the USA (scourvax-reo) induced protection in five gnotobiotic calves seven to 21 days later against a UK isolate of pathogenic bovine rotavirus. However, no protection was induced in three calves challenged three to five days after vaccination. There was a close antigenic relationship demonstrated between the two bovine rotavirus isolates. In contrast only one of three gnotobiotic calves inoculated with foal rotavirus, and one of three with human rotavirus, were protected against bovine rotavirus challenge. Protection in these two calves correlated with high heterologous immunofluorescent antibody titre (320 or greater), although the neutralising antibody titres was less than 20.
No takes yet. Share an insight, caveat, or question.
Woode et al. (1978) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: