Why the study?
Does a single oral dose of bovine rotavirus vaccine RIT 4237 reduce the incidence and severity of rotavirus diarrhoea in newborn infants?
Population
489 5-day-old infants, born in October 1984 (n=244) and June 1985 (n=245)
Comparison
Single oral dose of bovine rotavirus vaccine RIT… vs Placebo
Design
RCT
Follow-up
2.8 years (October group) and 2.0 years (June group)
Authors
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Supports newborn rotavirus vaccination to reduce diarrhoea severity; extends evidence for pre-season dosing in prevention trials.
Does a single oral dose of bovine rotavirus vaccine RIT 4237 reduce the incidence and severity of rotavirus diarrhoea in newborn infants?
A single oral dose of bovine rotavirus vaccine RIT 4237 reduces the clinical severity of rotavirus diarrhoea in newborn infants, with greater efficacy when given immediately before the epidemic season.
Ruuska et al. (1990) studied this question.
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