Why the study?
Do rhesus rotavirus or RIT 4237 bovine rotavirus vaccines prevent rotavirus diarrhea in Navajo infants?
Population
321 infants aged 2-5 months in a Navajo population
Comparison
One dose of either 10 pfu of rhesus rotavirus… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
17 months
Authors
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Neither vaccine prevents rotavirus diarrhea in Navajo infants; challenges efficacy assumptions and directs research to alternative candidates or populations.
Do rhesus rotavirus or RIT 4237 bovine rotavirus vaccines prevent rotavirus diarrhea in Navajo infants?
Neither the rhesus rotavirus vaccine nor the RIT 4237 bovine rotavirus vaccine demonstrated efficacy in preventing rotavirus diarrhea in a Navajo infant population.
Santosham et al. (1991) studied this question.
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