Why the study?
Does one, two, or three doses of RIT 4237 attenuated bovine rotavirus vaccine prevent diarrheal illness in children aged 2-18 months?
Population
391 children, 2-18 months old, in Lima, Peru
Comparison
One, two, or three doses of RIT 4237 attenuated… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
18 months
Authors
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Supports three-dose RIT 4237 vaccination in infants; extends evidence for bovine rotavirus vaccines against severe disease in endemic settings.
Does one, two, or three doses of RIT 4237 attenuated bovine rotavirus vaccine prevent diarrheal illness in children aged 2-18 months?
Three doses of the RIT 4237 rotavirus vaccine provided significant protection against severe rotaviral diarrhea, particularly serotype 1, in Peruvian children.
Lanata et al. (1989) studied this question.
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