Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing)
Why the study?
Does antibody administration protect mice from fatal infection with neurally spreading reovirus type 3?
Population
Mice infected with neurally spreading reovirus type 3 (Dearing) (T3) via footpad or intracerebral challenge
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Antibody protection viable after established CNS infection in mice; leaves open translation to human therapies or other viruses.
Structured PICO
Does antibody administration protect mice from fatal infection with neurally spreading reovirus type 3?
P
Population
Mice infected with neurally spreading reovirus type 3 (Dearing) (T3) via footpad or intracerebral challenge
I
Intervention
Polyclonal and monoclonal antibodies (including neutralizing and nonneutralizing, and those directed against viral cell attachment protein sigma 1)
O
Outcome
Protection from fatal infectionhard clinical
Antibody-mediated protection against neurally spreading reovirus type 3 does not require neutralizing activity or serum complement and is effective even after established CNS infection.
Cite This Study
Virgin et al. (1988) studied this question.