The determination of the VP7 gene sequence of the HO-5 equine rotavirus strain provides genetic information that may be useful for developing a vaccine for equine rotavirus infection.
VP7 sequence data may aid equine rotavirus vaccine antigen selection; leaves open efficacy in prospective equine trials.
The sequence of the VP7-encoded gene of a serotype G3 equine rotavirus strain HO-5 isolated in Japan was determined. The VP7 was amplified by a reverse transcription-polymerase chain reaction from the segment 8 RNA of the HO-5 strain by using a synthetic primer pair for the rotavirus VP7 gene. The gene segment 8 of the HO-5 strain was also sequenced and the deduced amino acid sequence was determined. The results indicate that the VP7 of the HO-5 strain is encoded by the gene segment 8 and the deduced amino acid sequence of the HO-5 VP7 has an overall high sequence homology more than 95% to those of two known equine rotavirus strains.
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Tsubokura et al. (1996) studied this question.
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