What question did this study set out to answer?

This research aims to investigate the relationship between mutations in the FAT/CD36 gene and the impaired uptake of long-chain fatty acids in the heart.

May 1, 2001Journal of Lipid ResearchOpen Access

Defect in human myocardial long-chain fatty acid uptake is caused by FAT/CD36 mutations

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Population

47 patients who showed total lack of the accumulation of a radiolabeled long-chain fatty acid analogue in…

Design

Case_series

Authors

TTTakao TanakaSuntory Foundation for Life Sciences TNTomoaki NakataCardiac Imaging TOTakanori OkaKansai Medical University

Discussion

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Implication

FAT/CD36 mutations may underlie defective myocardial LCFA uptake in rare cases; hypothesis-generating and should not yet change practice.

Key Points

This research aims to investigate the relationship between mutations in the FAT/CD36 gene and the impaired uptake of long-chain fatty acids in the heart.
Analyzed mutations and protein expression of the FAT/CD36 gene in 47 patients.
Used radiolabeled LCFA analogues to evaluate myocardial LCFA metabolism.
Determined the absence of FAT/CD36 protein on platelet and monocyte membranes.
All patients exhibited two mutations in the FAT/CD36 gene.
No FAT/CD36 protein expression was detected on membranes.
Results indicate a direct link between FAT/CD36 mutations and lack of LCFA accumulation in the heart.

Structured PICO

Population

47 patients who showed total lack of the accumulation of a radiolabeled long-chain fatty acid (LCFA) analogue in the heart

Outcome

Mutations and protein expression of the FAT/CD36 genesurrogate

Mutations in the FAT/CD36 gene are directly linked to a total defect in myocardial long-chain fatty acid accumulation in humans.

Cite This Study

Tanaka et al. (2001) studied this question.

synapsesocial.com/papers/6a6fb5285d37378ac1dcc486 https://doi.org/10.1016/s0022-2275(20)31637-0

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Defect in human myocardial long-chain fatty acid uptake is caused by FAT/CD36 mutations

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Defect in human myocardial long-chain fatty acid uptake is caused by FAT/CD36 mutations

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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