October 4, 2011Critical Care Medicine
Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies*
Why the study?
Does levosimendan reduce mortality and hospital stay in adult patients in cardiac surgery and cardiology settings?
Population
5,480 adult patients from 45 randomized clinical trials in cardiac surgery and cardiology settings
Comparison
Levosimendan vs Control (placebo or dobutamine)
Design
Meta-analysis, random allocation to treatment
Authors
Discussion
Loading...
Member takes
Implication
Supports levosimendan to reduce mortality in cardiac surgery and cardiology; confirms benefit versus placebo or dobutamine.
Structured PICO
Does levosimendan reduce mortality and hospital stay in adult patients in cardiac surgery and cardiology settings?
P
Population
5,480 adult patients from 45 randomized clinical trials in cardiac surgery and cardiology settings
I
Intervention
Levosimendan (non-oral administration, no restrictions on dose or time)
C
Comparator
Control (placebo or dobutamine)
O
Outcome
Mortalityhard clinical
Levosimendan significantly reduces mortality and length of hospital stay compared to control (placebo or dobutamine) in adult patients in cardiac surgery and cardiology settings.
Cite This Study
Landoni et al. (2011) studied this question.