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July 27, 2014Journal of the Renin-Angiotensin-Aldosterone System

ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis

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Why the study?

Does losartan increase ACE2 activity and inhibit atherosclerosis in a rabbit model of atherosclerosis?

Population

New Zealand white rabbits with atherosclerosis induced by high-cholesterol diet for 3 months, and smooth…

Design

Preclinical

Follow-up

3 months

Authors

YZYue Hui ZhangShandong UniversityQHQing HaoHubei University of Chinese MedicineXWXiaoyu WangNortheast Forestry University

Discussion

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Implication

Does not support clinical use; hypothesis-generating for losartan’s ACE2-mediated effects in atherosclerosis.

Structured PICO

Does losartan increase ACE2 activity and inhibit atherosclerosis in a rabbit model of atherosclerosis?

P
Population
New Zealand white rabbits with atherosclerosis induced by high-cholesterol diet for 3 months, and smooth muscle cells (SMCs) in vitro
I
Intervention
Losartan 25 mg/kg/d for 3 months (in vivo) and in vitro
O
Outcome
ACE2 activity and extent of atherosclerosissurrogate

Losartan upregulates ACE2 activity and inhibits atherosclerosis progression in a rabbit model, suggesting a potential mechanism for its anti-atherosclerotic effects.

Cite This Study

Zhang et al. (2014) studied this question.

synapsesocial.com/papers/6a6fb6516ceb2bbd16dfb798https://doi.org/10.1177/1470320314542829
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