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August 22, 2005Journal of Histochemistry & Cytochemistry

Immunolocalization of ACE2 and AT 2 Receptors in Rabbit Atherosclerotic Plaques

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Population

New Zealand White rabbits (n=16)

Comparison

0.5% cholesterol diet for 12 weeks vs Control diet for 12 weeks

Design

Preclinical

Follow-up

12 weeks

Authors

AZAnthony ZulliVictoria School of ManagementLBLouise M. BurrellHeart Failure & TransplantRWRobert E. WiddopGeneral Cardiology

Discussion

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Implication

AT2R/ACE2 expression in rabbit plaque cells suggests a role in atherogenesis; leaves open human relevance and therapeutic targeting.

Structured PICO

P
Population
New Zealand White rabbits (n=16)
I
Intervention
0.5% cholesterol diet for 12 weeks
C
Comparator
Control diet for 12 weeks
O
Outcome
Localization of ACE2 and AT2R in thoracic aorta tissues and identification of expressing cell typessurrogate

ACE2 and AT2R are expressed by macrophages and smooth muscle cells in rabbit atherosclerotic plaques, suggesting a potential role in atherogenesis.

Cite This Study

Zulli et al. (2005) studied this question.

synapsesocial.com/papers/6a6fb6516ceb2bbd16dfb79fhttps://doi.org/10.1369/jhc.5c6782.2005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases1998 · 479 citations
  2. 2The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.1995 · 682 citations
  3. 3Angiotensin II AT<sub>2</sub> receptor inhibits smooth muscle cell migration via fibronectin cell production and binding2002 · 21 citations
  4. 4Angiotensin II Type 2 Receptor Inhibits Cell Proliferation and Activates Tyrosine Phosphatase1996 · 102 citations
  5. 5Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E–Deficient Mice2002 · 263 citations