Why the study?
Does recombinant ACE2 expressing vector improve plaque stability in a rabbit model of atherosclerosis?
Population
114 rabbits with atherosclerotic plaques induced in the abdominal aorta by endothelial injury and…
Comparison
Recombinant ACE2 expressing vector gene therapy… vs Control vector AdEGFP or AdACE2+A779
Design
Preclinical, Rabbits were randomly divided into 3 subgroups
Follow-up
Up to 16 weeks
Authors
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May stabilize plaques in rabbit atherosclerosis; extends preclinical data but leaves open human translation.
Does recombinant ACE2 expressing vector improve plaque stability in a rabbit model of atherosclerosis?
ACE2 overexpression stabilizes atherosclerotic plaques in a rabbit model, likely by converting vasoconstrictive angiotensin II to vessel-protective angiotensin 1-7.
Dong et al. (2008) studied this question.
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