July 31, 2010Journal of Biological ChemistryOpen Access

Neuropilin-1 Mediates Divergent R-Smad Signaling and the Myofibroblast Phenotype

View Full Paper

Ask AI

Bookmark

Population

Stromal fibroblast cell lines and hepatic stellate cells (HSCs) stimulated with TGF-β

Design

Preclinical

Authors

YCYing CaoXinjiang Medical University ASAnnamária SzabolcsHarvard University SDShamit K. DuttaJacksonville College

Discussion

Member takes

Implication

NRP-1 may promote myofibroblast activation; leaves open therapeutic targeting in human fibrosis.

Structured PICO

Population

Stromal fibroblast cell lines and hepatic stellate cells (HSCs) stimulated with TGF-β

Intervention

Elimination of neuropilin-1 (NRP-1)

Outcome

Smad signaling (Smad1/5 and Smad2/3 phosphorylation) and myofibroblast phenotype (Id-1, α-SMA expression, growth arrest)surrogate

NRP-1 functions as a key determinant of diverse responses downstream of TGF-β1 mediated by distinct Smad proteins, promoting the myofibroblast phenotype.

Cite This Study

Cao et al. (2010) studied this question.

synapsesocial.com/papers/6a6fb6c0e5469ee92be09220 https://doi.org/10.1074/jbc.m110.151696

View Full Paper

Ask AI

Bookmark

Neuropilin-1 Mediates Divergent R-Smad Signaling and the Myofibroblast Phenotype

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neuropilin-1 Mediates Divergent R-Smad Signaling and the Myofibroblast Phenotype

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider