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October 12, 2023AJP Renal Physiology

Neuropilin 1 promotes unilateral ureteral obstruction-induced renal fibrosis via RACK1 in renal tubular epithelial cells

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Key result

Neuropilin 1 (NRP1) promotes renal fibrosis by stimulating the TGF-β1 signaling pathway, possibly through binding to RACK1 in renal tubular epithelial cells.

Why the study?

Although studies have linked neuropilin 1 (NRP1) to renal diseases, the mechanism of NRP1 in renal fibrosis remains unclear.

Design

In vitro and in vivo preclinical study

Authors

LHLing HouWuhan Children's Hospital

Discussion

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Implication

Does not support clinical targeting of NRP1; leaves open its therapeutic relevance pending in vivo validation.

Structured PICO

P
Population
In vitro and in vivo models of unilateral ureteral obstruction-induced renal fibrosis (renal tubular epithelial cells)
E
Exposure
Neuropilin 1 (NRP1) modulation
O
Outcome
Renal fibrosis and TGF-β1 signaling pathway activationsurrogate

NRP1 promotes renal fibrosis by stimulating the TGF-β1 signaling pathway via RACK1 binding, identifying a potential therapeutic target for renal diseases.

Cite This Study

Ling Hou (2023) studied Renal fibrosis. Neuropilin 1 (NRP1) was evaluated on Renal fibrosis and TGF-β1 signaling pathway activation. Neuropilin 1 (NRP1) promotes renal fibrosis by stimulating the TGF-β1 signaling pathway, possibly through binding to RACK1 in renal tubular epithelial cells.

synapsesocial.com/papers/6aa29a4874fc654bd03238b5https://doi.org/10.1152/ajprenal.00069.2023
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