Why the study?
Does diltiazem alter the aortic pressure-diameter relationship and aortic stiffness in anesthetized dogs?
Population
10 anesthetized dogs
Comparison
Diltiazem infusion vs Baseline (before diltiazem infusion)
Design
Preclinical
Authors
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Cubic modeling fits canine aortic curves with or without diltiazem; leaves open translation to human stiffness.
Does diltiazem alter the aortic pressure-diameter relationship and aortic stiffness in anesthetized dogs?
In a canine model, the aortic pressure-diameter relationship before and after diltiazem infusion follows a sigmoid curve that can be accurately described by a cubic equation.
Yano et al. (1989) studied this question.
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