Smooth muscle relaxation and local hydraulic impedance properties of the aorta
Why the study?
Does intravenous diltiazem infusion alter aortic wall stiffness and local hydraulic impedance properties in anesthetized dogs?
Population
7 anesthetized, closed-chest dogs
Comparison
Intravenous diltiazem infusion vs Control condition (baseline)
Design
Preclinical
Authors
Discussion
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Implication
Diltiazem may not improve aortic impedance despite BP reduction in dogs; leaves open translation of smooth muscle effects to clinical aortic mechanics.
Structured PICO
Does intravenous diltiazem infusion alter aortic wall stiffness and local hydraulic impedance properties in anesthetized dogs?
P
Population
7 anesthetized, closed-chest dogs
I
Intervention
Intravenous diltiazem infusion
C
Comparator
Control condition (baseline)
O
Outcome
Aortic wall stiffness and local hydraulic impedance properties (instantaneous cross-sectional area and pressure of the descending thoracic aorta)surrogate
Smooth muscle relaxation with diltiazem does not necessarily produce beneficial changes in local aortic hydraulic impedance due to competing effects of changes in vessel diameter and wall stiffness.
Cite This Study
Cholley et al. (2001) studied this question.