What question did this study set out to answer?

This study examines the effects of various vasoactive drugs on the elastic properties of human arteries.

Vasoactive drugs and elastic properties of human arteries in vivo, with special reference to the action of nitroglycerine

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Why the study?

Do vasoactive drugs, specifically nitroglycerine, alter arterial compliance in human arteries in vivo?

This study examines the effects of various vasoactive drugs on the elastic properties of human arteries.
Recorded volume changes in an arm segment using an air-filled plethysmograph.
Modified transmural arterial pressure via a pressure chamber around the arm.
Calculated arterial compliance at late diastole under varying pressures.
Arterial compliance increased significantly with nitroglycerine without altering cardiac output or arterial pressure.
Noradrenaline and hypertensin did not affect arterial compliance values.
Dihydroergotamine led to a reduction in arterial compliance.

Do vasoactive drugs, specifically nitroglycerine, alter arterial compliance in human arteries in vivo?

Population

Human subjects (in vivo study of arm segment arteries)

Intervention

Vasoactive drugs (noradrenaline, hypertensin, dihydroergotamine, nitroglycerine)

Outcome

Arterial compliance valuessurrogate

Nitroglycerine significantly increases arterial compliance in vivo independent of changes in cardiac output and arterial pressure.

Authors

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Nitroglycerine effects on compliance merit re-evaluation in current practice; leaves open applicability to modern populations and endpoints.

Westling et al. (1984) studied this question.

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Nitroglycerine effects on compliance merit re-evaluation in current practice; leaves open applicability to modern populations and endpoints.