December 2, 1983European Heart Journal

The biochemistry of uncontrolled calcium entry

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Population

Isolated spontaneously beating Sprague-Dawley rat hearts

Comparison

Perfusion with Ca2+-free buffer for >1 min… vs Ca2+ repletion without Co2+/Mn2+ or with…

Design

Preclinical

Authors

WNW. G. NaylerCross-Cutting Cardiology JEJ. S. ElzThe University of Melbourne SPS E PerryTulane University

Discussion

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Implication

Challenges slow Ca2+ channel involvement in the paradox in rat hearts; hypothesis-generating for reperfusion mechanisms with no clinical implications yet.

Structured PICO

Population

Isolated spontaneously beating Sprague-Dawley rat hearts

Intervention

Perfusion with Ca2+-free buffer for >1 min followed by Ca2+ repletion, with addition of 2-4 mmol l-1 Co2+ or Mn2+ before, during but not coincident with Ca2+ repletion, or preloading with Na+

Comparator

Ca2+ repletion without Co2+/Mn2+ or with Co2+/Mn2+ added at the time of Ca2+ repletion

Outcome

Myoglobin release, Ca2+ overload, and structural changes (glycocalyx distortion, intercalated disc integrity)surrogate

The uncontrolled entry of Ca2+ during the Ca2+ paradox in isolated rat hearts does not appear to depend on entry through slow channels or splitting of the basement coat.

Cite This Study

Nayler et al. (1983) studied this question.

synapsesocial.com/papers/6a6fb8c3f44fa9f079dd3226 https://doi.org/10.1093/eurheartj/4.suppl_h.29

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Implication

Challenges slow Ca2+ channel involvement in the paradox in rat hearts; hypothesis-generating for reperfusion mechanisms with no clinical implications yet.

The biochemistry of uncontrolled calcium entry

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The biochemistry of uncontrolled calcium entry

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider