Population
Primary cardiac myofibroblasts (in vitro model)
Comparison
Pharmacologic inhibition of NCX1, NSCC, calcium… vs Untreated/control conditions
Design
Preclinical
Authors
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NCX1 inhibition may modulate post-infarct remodeling; leaves open translation from animal myofibroblast data to in vivo or clinical benefit.
Inhibition of the Na+-Ca2+ exchanger (NCX1) suppresses cardiac myofibroblast motility, contraction, and proliferation, suggesting it may be a potential target for modulating post-infarct cardiac remodeling.
Raizman et al. (2007) studied this question.
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