March 1, 2003Cardiovascular ResearchOpen Access

Activation and inactivation of a non-selective cation conductance by local mechanical deformation of acutely isolated cardiac fibroblasts

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Population

Isolated rat atrial fibroblasts

Comparison

Mechanical deformation using two patch-pipettes vs Baseline resting state

Design

Preclinical

Authors

AKAndre KamkinPirogov Russian National Research Medical University

Discussion

Member takes

Implication

Identifies mechano-sensitive currents in fibroblasts; leaves open relevance to human arrhythmias or in vivo mechano-electrical feedback.

Structured PICO

Population

Isolated rat atrial fibroblasts

Intervention

Mechanical deformation (compression or stretch by 2 or 3 micrometers) using two patch-pipettes

Comparator

Baseline resting state

Outcome

Membrane potential (E(0)) and ionic currentssurrogate

Mechanical compression and stretch of cardiac fibroblasts modulate a non-selective cation conductance, providing a potential cellular mechanism for mechano-electrical feedback in the heart.

Cite This Study

Andre Kamkin (2003) studied this question.

synapsesocial.com/papers/6a79bf785968508e56f391ca https://doi.org/10.1016/s0008-6363(02)00775-7

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Activation and inactivation of a non-selective cation conductance by local mechanical deformation of acutely isolated cardiac fibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation and inactivation of a non-selective cation conductance by local mechanical deformation of acutely isolated cardiac fibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider