Key result
Rhythmic contractions of the myocardium produce reversible mechanically induced potentials in human cardiac fibroblasts, appearing with a delay of 40.0 ± 0.4 ms after the cardiomyocyte action potential.
Population
Fibroblasts from human right atrium
Design
Preclinical
Authors
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May implicate fibroblasts in mechano-electrical feedback; leaves open relevance to human arrhythmia risk.
Human right atrial fibroblasts are mechanosensitive and generate mechanically induced potentials that may play a role in cardiac mechano-electrical feedback.
Kamkin et al. (1999) studied Human right atrium fibroblasts. Mechanical stretch and intracellular polarization was evaluated on Mechanically induced potentials (MIPs). Rhythmic contractions of the myocardium produce reversible mechanically induced potentials in human cardiac fibroblasts, appearing with a delay of 40.0 ± 0.4 ms after the cardiomyocyte action potential.
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