January 25, 2010Acta Physiologica

Single mechano‐gated channels activated by mechanical deformation of acutely isolated cardiac fibroblasts from rats

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Population

Acutely isolated atrial fibroblasts from rats

Comparison

Mechanical deformation and pharmacological… vs Resting conditions

Design

Preclinical

Authors

AKAndre KamkinPirogov Russian National Research Medical University SKSergei KirischukJohannes Gutenberg University Mainz IKIrina KiselevaUral Federal University

Discussion

Member takes

Implication

Directional MGC responses in rat atrial fibroblasts are hypothesis-generating; leaves open their role in human cardiac mechano-electrical coupling.

Structured PICO

Population

Acutely isolated atrial fibroblasts from rats

Intervention

Mechanical deformation (compression and stretch of 1-4 micrometers) and pharmacological blockade (Gd3+, cytochalasin D, colchicine)

Comparator

Resting conditions

Outcome

Currents through single mechano-gated channels and mechanosensitive whole-cell currentssurrogate

Rat atrial fibroblasts express mechano-gated channels that respond directionally to mechanical stress, contributing to cardiac mechano-electrical coupling.

Cite This Study

Kamkin et al. (2010) studied this question.

synapsesocial.com/papers/6a7cc1b152489361ef8ce770 https://doi.org/10.1111/j.1748-1716.2010.02086.x

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Implication

Directional MGC responses in rat atrial fibroblasts are hypothesis-generating; leaves open their role in human cardiac mechano-electrical coupling.

Single mechano‐gated channels activated by mechanical deformation of acutely isolated cardiac fibroblasts from rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Single mechano‐gated channels activated by mechanical deformation of acutely isolated cardiac fibroblasts from rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider