Key result
Stretch of mechanosensitive fibroblasts during atrial diastole raised the spontaneous depolarization rate of modeled sino-atrial pacemaker cells by up to 24%.
Population
Isolated spontaneously beating atrium of rat hearts, cell cultures of neonatal rat heart, and a mathematical…
Design
Preclinical
Authors
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Hypothesis-generating for fibroblast-pacemaker coupling in sinus node; requires in vivo validation before any clinical relevance.
Cardiac mechanosensitive fibroblasts coupled to sino-atrial pacemaker cells may mediate the positive chronotropic response to right atrial stretch.
Köhl et al. (1994) studied Mechano-electric feedback in the sino-atrial node. Stretch of mechanosensitive fibroblasts was evaluated on Spontaneous depolarization rate of the pacemaker cell. Stretch of mechanosensitive fibroblasts during atrial diastole raised the spontaneous depolarization rate of modeled sino-atrial pacemaker cells by up to 24%.
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