Population
Mathematical models of human atrial myocytes and myofibroblasts
Comparison
Simulation of electrotonic myofibroblast-myocyte… vs Simulations with varying intercellular coupling…
Design
Preclinical
Authors
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May implicate myofibroblast channels in fibrotic arrhythmogenesis; hypothesis-generating and requires in vivo validation before clinical consideration.
Mathematical modeling demonstrates that sodium and mechanogated channels in myofibroblasts significantly alter atrial myocyte electrophysiology, highlighting their potential role in arrhythmogenesis during fibrotic remodeling.
Zhan et al. (2016) studied this question.
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