Why the study?
Sudden cardiac death in patients receiving atypical antipsychotics may be related to QTc prolongation, motivating an investigation into risk factors to guide clinical practice and prevent prolonged QTc.
What are the risk factors for QTc prolongation in schizophrenia patients receiving atypical antipsychotics?
What are the risk factors for QTc prolongation in schizophrenia patients receiving atypical antipsychotics?
Male sex, older age, low HDL, and higher antipsychotic doses are significant risk factors for QTc prolongation in schizophrenia patients on atypical antipsychotics, warranting closer monitoring.
PURPOSE: The risk of sudden cardiac death in patients receiving atypical antipsychotics may be related to QTc prolongation. The aim of this study was to investigate the risk factors for QTc prolongation to prevent QTc prolongation and guide clinical practice. METHODS: All electrocardiogram recordings of 913 schizophrenia patients who were receiving atypical antipsychotics were reviewed for prolonged QTc and associated conditions. Binary logistic regression analysis was used to investigate risk factors for QTc prolongation. RESULTS: Logistic regression analysis demonstrated that sex (odds ratio [OR], 0.386; P = 0.010), age (OR, 1.047; P = 0.000), high-density lipoprotein (OR, 0.257; P = 0.014), and antipsychotics dose (OR, 1.040; P = 0.036) were significantly associated with QTc prolongation. CONCLUSIONS: In patients with male sex, elder age, low high-density lipoprotein, or large antipsychotics dose, QTc should be monitored more frequently.
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He et al. (2021) studied this question.
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