Why the study?
Sex hormones control various physiological functions, prompting this review on sex hormonal regulation of K+ channels and its effects on electrophysiological and contractile functions of muscles.
Sex hormones regulate K+ channels in muscle tissues, influencing cardiac action potential duration, ischemic preconditioning, and uterine arterial contraction.
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Clinicians should factor sex hormones into QT/arrhythmia risk assessment; leaves open prospective validation in targeted populations.
Sakamoto et al. (2019) studied this question.
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