Why the study?
Does the combined estimation of probability density of blood pressure and R-R intervals improve the reproducibility and sensitivity of spontaneous baroreflex estimation compared to traditional approaches?
Does the combined estimation of probability density of blood pressure and R-R intervals improve the reproducibility and sensitivity of spontaneous baroreflex estimation compared to traditional approaches?
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A new method for calculating spontaneous arterial baroreflex sensitivity using combined probability density of blood pressure and R-R intervals may improve the diagnosis of autonomic dysfunction.
Autonomic dysfunction is associated with negative prognosis in cardiovascular patiens and several other pathologies. Arterial baroreflex sensitivity is an important marker of autonomic regulation. Present work is devoted to the new approach to spontaneous baroreflex estimation, which permit to improve quality of the continious blood pressure and ECG monitoring analysis. The method of combined estimation of probability density of blood pressure and R-R intervals is proposed in this article, which improves efficacy of use of date records due to the increased number of included beats in calculation. This method is appeared to have better reproducibility and, probably, sensitivity for autonomic dysfunction diagnosis compared to traditional approaches. Moreover, offered method allow to measure additional arterial barorexlex characteristics. Thus, the calculation of barorexlex sensitivity combined probability density allows to wide the sphere of spontaneous baroreflex estimation, including changeable conditions.
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Bogachev et al. (2007) studied this question.
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