Cohort Profile: The Diabetes Study of Northern California (DISTANCE)—objectives and design of a survey follow-up study of social health disparities in a managed care population†

One of the challenges of the national initiative, Healthy People 2010,1 is to support interventions that will reduce social disparities in health. While social disparities such as differences in education, income, race or ethnicity may affect health, the mechanisms are poorly understood. If social disparities in health originate in childhood, are current social disparities in health modifiable and are they the responsibility of a medical provider or health plan? Nonetheless, modifiable factors may exist at the individual, neighbourhood or system level that mediate (explain) social disparities in health and that may be suitable targets for interventions aiming to reduce disparities. Our aim was to survey and prospectively follow a large, diverse and well-characterized population with diabetes and to collect data on risk factors which may affect diabetes health outcomes but which may differ substantively in prevalence or effect size across ethnic groups or educational levels. The 2002 Institute of Medicine report, ‘Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care’,2 detailed the socioeconomic fragmentation of health care quality and access, and its differential, negative impact on minorities. As access to health care is an important determinant of health outcomes and is in turn associated with ethnicity and socioeconomic position, it represents a potent source of confounding bias in population-based studies of social health disparities. At the population level, identifying antecedents and determinants of social differences in disease progression remains a challenge. There are nationally representative surveys (e.g. National Health and Nutrition Examination Survey) that identify members of the general population with diabetes and that can estimate risk factors that are associated with diabetes complications, but these cohorts are often cross-sectional or panel studies and have limited ability to track continuous changes in individual-level health care, outcomes and risk factors over time. Longitudinal, population-based studies often have too few minority subjects with diabetes to reveal racial or ethnic differences. The relatively uniform access to care in a managed care health plan such as Kaiser Permanente provides an advantageous setting in which to conduct a longitudinal study of social disparities in health and study findings may be compared with population-based studies, where health care access and quality may vary by socioeconomic position. We established the Kaiser Permanente Northern California Diabetes Registry (‘Registry’) in 1993 using standardized criteria (Table 1) to identify and prospectively follow members with diabetes, to measure prevalence and incidence of diabetes and its co-morbidities, to understand factors associated with disease progression and complications, and to evaluate health care processes and outcomes. The Registry has an estimated sensitivity of 99% based on chart review validation (unpublished results). We conducted the first survey of the Registry in 1994–97 (Diabetes Registry Questionnaire) among all Registry members over 19 years of age. The primary goal of that survey was to capture individual-level information on the clinical characteristics of diabetes, age at diagnosis, ethnicity, education, health-related behaviours and diabetes family history. There were 77 726 respondents (83% response rate among eligible members) and that survey cohort has been the basis for numerous publications regarding the epidemiologic and health services aspects of diabetes.3–9 Inclusion and exclusion criteria for the Kaiser Permanente Northern California Diabetes Registrya aThe Registry is updated annually. Inclusion and exclusion criteria for the Kaiser Permanente Northern California Diabetes Registrya aThe Registry is updated annually. We previously reported findings regarding ethnic disparities in the incidence of myocardial infarction, stroke, congestive heart failure, end-stage renal disease and lower-extremity amputation among diabetic African American, Asian, Latino and Caucasian members of Kaiser Permanente Northern California (‘Kaiser’),7 a population with uniform access to care.10 Socioeconomic disparities in diabetic complications based on educational attainment and income have been reported in other populations.11,12 The National Institutes of Health provided funding to the Kaiser Division of Research and the University of California, San Francisco School of Medicine, to conduct the Diabetes Study of Northern California (DISTANCE). This study was approved by their respective Institutional Review Boards. We developed and implemented DISTANCE as a survey follow-up cohort study13 to assess a wide range of social and behavioural factors that we hypothesized to be potentially confounding, moderating or mediating factors associated with social disparities in diabetes-related outcomes. The DISTANCE Survey consisted of 184 questions and the domains included demographics, socioeconomics, clinical profile, health behaviours, treatment adherence, diabetes knowledge, psychosocial characteristics, patient–provider relationship and quality and access to care (Table 2). Every effort was made to create a survey with language, font and layout that would be accessible to non-English speakers and persons of low literacy or visual acuity.14,15 The complete survey is available as Supplementary data and at http://distancesurvey.org. Clinical, behavioral, psychosocial and quality and access indicators years of school highest degree attained quality-weighted attainment functional health literacy smoking alcohol exercise medication refill adherence and discontinuation self-monitoring of blood glucose insulin injection frequency appointment-keeping adherence health screening adherence sleep adequacy years of school highest degree attained quality-weighted attainment functional health literacy smoking alcohol exercise medication refill adherence and discontinuation self-monitoring of blood glucose insulin injection frequency appointment-keeping adherence health screening adherence sleep adequacy Clinical, behavioral, psychosocial and quality and access indicators years of school highest degree attained quality-weighted attainment functional health literacy smoking alcohol exercise medication refill adherence and discontinuation self-monitoring of blood glucose insulin injection frequency appointment-keeping adherence health screening adherence sleep adequacy years of school highest degree attained quality-weighted attainment functional health literacy smoking alcohol exercise medication refill adherence and discontinuation self-monitoring of blood glucose insulin injection frequency appointment-keeping adherence health screening adherence sleep adequacy Our two primary exposures/attributes of interest were self-reported race/ethnicity and education (years of education and degrees earned). Other social factors surveyed included country of birth, acculturation and language fluency, subjective socioeconomic position16,17 and several objective measures of socioeconomic position: educational attainment of self,18,19 parents and spouse,20 individual employment,21,22 household income,23 assets,23,24 marital status and family size. The survey included extensive questions on health behaviours and self-reported symptoms not readily available in administrative data: diet,25 physical activity,26 smoking,21 alcohol consumption,27 self-monitoring of blood glucose (SMBG),25 oral health,28,29 self-examination of feet,25 medication adherence,25,30,31 multivitamin use,32 TV watching,20 attitudes and beliefs about diabetes,23 internal vs external locus of control,33,34 social support,23,35–37 health status,38,39 stress,40 depression,22,41–43 sleep quality,44–46 chronic pain,38 personality traits,47–49 health literacy,50–52 diabetes knowledge,53,54 medical and dental coverage, medical costs and ability to pay,55 medical visit travel time,43 language barriers, delayed treatment,56 provider recommendations regarding aspirin43 and SMBG,43 foot exam by physician,43 quality of care,43 discrimination,57,58 provider communication and interactions,59,60 trust in provider61,62 and self-reported height, weight,43 symptoms, complications,43 erectile dysfunction or female urinary incontinence. The survey included four modes of administration: (i) a computer-assisted telephone interview (CATI) administered by a third party, (ii) a password-enabled, internet-accessible survey (‘web survey’) maintained on a secure server at the Kaiser Division of Research, (iii) a self-administered, written survey or (iv) a short version of the written survey. The content of each survey mode was identical except for slight adjustments in wording and logic patterns as needed and was estimated to take 45–60 min to complete; the short written version was abridged and contained 40 questions. The written and web surveys were in English only, but the CATI was available in English, Spanish, Cantonese, Mandarin and Tagalog using certified translations of an English script and was intended to maximize accessibility to those with language barriers or limited English literacy or fluency. We geocoded the home addresses of all respondents and non-respondents and linked their census block group and tract to 2000 Census data. These census characteristics were then factor-analysed, and we developed an eight-item ‘deprivation index’ as a way of summarizing the many indicators. The deprivation index has excellent internal reliability (Cronbach alpha = 0.93) with each of the eight items loading almost equally onto the underlying construct. Baseline clinical characterizations were obtained from the extensive Kaiser administrative databases including smoking status, body mass index, current pharmacotherapy utilization and adherence,63 laboratory findings, history of co-morbid events and procedures, use of emergency room, outpatient and inpatient health services, costs, outpatient and inpatient risk scores based on health care utilization and severity of disease64 and end-stage renal disease registry (linked to the United States Renal Data System). These data are available for all subjects, both respondents and non-respondents, and allow for a substantive assessment of survey response bias. This study took place within the Kaiser Foundation Health Plan, the largest not-for-profit managed health care company in the United States.65 Study subjects were members of Kaiser Permanente Northern California (KPNC) which provides comprehensive medical services to over 3.2 million members (as of January, 2005) in the San Francisco Bay and Sacramento metropolitan areas, or 25–30% of the region's population. KPNC members are predominantly employed or retired individuals and their families, and closely approximate the general population ethnically and socioeconomically except for the extreme tails of income distribution.6,66,67 The Diabetes Registry consisted of 199 123 members as of January 1, 2005, and from this we selected an ethnically stratified, random sample of 40 735 health plan members, aged 30–75 at baseline, to receive the DISTANCE Survey: 6871 African American (17%), 11 197 Asian (27%), 4233 Caucasian (10%), 7018 Latino (17%) and 11 417 members of unknown ethnicity (28%). The DISTANCE Survey was in the field from May 5, 2005 until December 31, 2006. The survey was completed by 20 188 persons (Table 3). The participation by ethnicity was 3420 African Americans (16.9%), 2312 Asian (11.4%), 4602 Caucasians (22.8%), 2404 Filipinos (11.9%), 3717 Latinos (18.4%), 2222 multi-racial (11.0%) and 1511 South Asian, Pacific Islander, Native America, Eskimo or other/unknown (7.5%). The distribution by mode was 10 429 CATI (51.7%), 4288 written survey (21.2%), 2393 short version (11.8%) and 3078 web (15.2%). Using an algorithm endorsed by the Council of American Survey Research Organizations (CASRO), if persons unable to be contacted had the same rate of eligibility as those contacted and were counted in the denominator, the survey response rate was 62%. Of the 20 188 respondents to this current survey, 4524 subjects (22%) had also responded to the prior Diabetes Registry Questionnaire (1994–97). Characteristics of survey respondents and non-respondents aIncludes Pacific Islanders, Native Americans, South Asian, other unspecified and unknown (did not answer). b≥20% continuous medication gaps.63 cThey are weighted by patient's health care utilization and severity of disease.64 d≥25% of households in census block group are linguistically isolated. e≥20% of households in census block group are living below poverty line. f≥66% of persons in census block group are employed in working class occupation. Characteristics of survey respondents and non-respondents aIncludes Pacific Islanders, Native Americans, South Asian, other unspecified and unknown (did not answer). b≥20% continuous medication gaps.63 cThey are weighted by patient's health care utilization and severity of disease.64 d≥25% of households in census block group are linguistically isolated. e≥20% of households in census block group are living below poverty line. f≥66% of persons in census block group are employed in working class occupation. The entire cohort has been characterized using demographic, clinical and behavioural data from administrative records and census data. African American respondents were more likely to be female, to have had English as their preferred language, to have had elevated levels of low-density lipoprotein (LDL), uncontrolled blood pressure, were current smokers, with higher co-morbidity scores and living in a deprived neighbourhood. Asian respondents were more likely to be male, over 60 years of age, to not have had English as their preferred language, to have had lower levels of LDL, better blood pressure control, lower missed appointment rate, better medication adherence, were non-smokers, not practicing SMBG, with lower co-morbidity scores and not living in an economically deprived or working class neighbourhood. Caucasian respondents were more likely to complete the survey online, to have had lower mean A1C, practicing SMBG and not living in linguistically isolated neighbourhood. Filipino respondents were more likely to participate via written survey, to have been older than 45 years of age, to have had lower levels of LDL and lower co-morbidity scores. Latino respondents were more likely to participate via CATI, to have been younger than 45 years of age, to not have English as their preferred language, to have had higher mean A1C, higher rates of missed appointments, poorer medication adherence and living in a linguistically isolated or working class neighbourhood. This cohort will be the basis for longitudinal evaluations of a wide range of clinical outcomes associated with diabetes and are powered to evaluate the ethnic and educational disparities in diabetes-related complication rates (e.g. myocardial infarction, stroke, heart failure, kidney failure and amputation) and mortality after a 2.5-year follow-up. Clinical and administrative follow-up data will be captured from these same sources as baseline, plus deaths from the state mortality files. Data from all sources combined may offer insights into how differences at the patient-level (e.g. differences in behaviours, type of therapy, intermediate health status and psychosocial factors, and competing demands), provider-level (e.g. trust in provider, racial concordance and patient-provider communication) and system-level (e.g. differential impact of cost-sharing) may lead to social disparities in diabetes health, end-stage diabetes complications and mortality. One of the strengths of this diabetes registry is the very low turnover rate (∼5% discontinue membership each year), affording minimal loss to follow-up. On average, the duration of Kaiser membership among our diabetes cohort members is 8.9 years (SD = 6.6). A significant weakness is that written and web surveys were only offered in English. However, telephone interviewers made the initial efforts to contact subjects who had the opportunity to complete interviews in Spanish, Mandarin, Cantonese or Tagalog. Offering the survey by oral interview in multiple languages was intended to mitigate the language and/or literacy barriers, but we still observed lower participation rates by those with less education and modest response differences by race. On a more favourable note, 84% of non-respondents were identified by the health plan as having English as their preferred language, suggesting that language alone was not a major barrier to participation. The response rate was, as expected, lower than our previous Diabetes Research Questionnaire (1994–97). A recent survey conducted in the Translating Research Into Action for Diabetes (TRIAD) study among managed care populations across the United States, including Kaiser,43 had a response rate of ∼50%. The Behavioural Risk Factor Surveillance System also experienced a decline in median response rates, from 63.2% in 1996 to 53.5% in 2001.68 Privacy concerns and competition from telemarketing have probably played a role in declining response rates. However, if generally lower response rates have been observed in minority populations, the response rate for this survey may be considered favourable given that 77% of our sample were racial or ethnic minority health plan members. One strength of this study is the relatively uniform access to care provided by membership in this integrated health plan. Thus, this study largely avoids disparities in access and quality, which are potent sources of confounding bias in population-based studies of social health disparities. Another strength is the quality and richness of the clinical follow-up data. Administrative and clinical data are available directly from the health plan and are considered to be reliable and complete. Each telephone interview was conducted by professional interviewers employed, trained and supervised by the Public Health Institute Survey Research Group in Sacramento, CA, which has its own internal quality controls. Written surveys (long- and short-forms) were coded and edited using an extensive data dictionary and detailed coding rules to standardize and clarify responses before being sent to the Data Entry department at the Kaiser Division of Research, which conducted double data entry. The survey data quality is limited by being self-reported. The diversity, size and wealth of data included in the DISTANCE cohort make it suitable for the prospective study of a wide range of social disparities in the processes and outcomes of diabetes health care. Information about childhood socioeconomic position and educational attainment will facilitate a life course approach.69,70 Response bias is a concern in any survey. Surveys are subject to response bias if participation is associated with the risk factors (exposures) and/or diseases (outcomes) under investigation. In this study population we have substantial data on non-respondents, including Kaiser administrative data, co-morbidity and census data on neighbourhood characteristics, allowing us to compare hypothesized relationships in respondents vs non-respondents and adjust for this potential response bias.71 While participation was somewhat lower among minorities and those with less education, overall, respondents and non-respondents were quite similar. We had pre-baseline reported race data for 29 319 (72%) members of the DISTANCE cohort and observed differences in response rates by race: African Americans 52%, Asians 46%, Caucasians 63%, Latinos 53%, unknown 45% We also had educational attainment data for 4524 subjects (22%) who had completed the previous survey in 1994–97 and observed that subjects with a school education or less at a lower rate than those with more than a school education vs A more complete of response bias was obtained from health plan administrative data and census data, which was available for all members of the We few differences respondents and non-respondents in demographic, behavioural or neighbourhood with non-respondents had higher mean LDL levels vs and were less likely to SMBG vs However, a of these differences are likely to age differences in respondents vs We conducted an assessment of response bias by differences in across ethnic groups among respondents and We a of which the on ethnicity, age and and an survey respondents had higher than non-respondents, ethnic differences in the relationship ethnicity and not differ respondents and non-respondents = We conducted a with the subjects for we had educational attainment data from a previous survey and substantive response bias = While characteristics differ respondents and non-respondents the with outcomes of interest are less to such of DISTANCE data will on than We will a using of to relationships in this These will to adjust for the (e.g. of the minority ethnic and response bias (e.g. to respondents who have characteristics more to the Thus, the will adjust for confounding and bias We are not to data under our to regarding However, the DISTANCE is in with external DISTANCE are in social disparities observed in this population with uniform access to care to disparities observed in population-based where quality and access to care vary by social for be to the of the can be review and by the DISTANCE and This was (i) and quality of DISTANCE (ii) the of the study and (iii) the and of were provided by National Institute of and and National Institute of Health and is also by a National Institutes of Health Clinical The Public Health Research Group conducted our telephone and provided certified translations of all and interview with Kaiser provided and services for the written surveys and other We and for their on survey of we all the study of