THE EFFECT OF A CELL‐PERMEABLE DIACYLGLYCEROL ANALOGUE ON SINGLE Ca2+ (Ba2+) CHANNEL CURRENTS IN THE INSULIN‐SECRETING CELL LINE RINm5F

View Full Paper

Ask AI

Bookmark

Population

Insulin-secreting cell line RINm5F

Design

Preclinical

Authors

Discussion

Does not inform clinical diabetes management; leaves open whether PKC mediates carbohydrate-evoked Ca2+ uptake in human beta cells.

Population

Insulin-secreting cell line RINm5F

Intervention

Didecanoylglycerol (DC10; 5 micrograms/ml)

Outcome

Proportion of time the 'L' type Ca2+ (Ba2+) channels spent in the open state during depolarizing voltage pulsessurrogate

The study suggests that carbohydrate-evoked cellular Ca2+ uptake in insulin-secreting cells may be mediated via protein kinase C activation.

Velasco et al. (1989) studied this question.

View Full Paper

Ask AI

Bookmark