Population
Insulin-secreting RINm5F cell line (saponin-permeabilized cells)
Comparison
ADP (100-500 microM) added to the bath solution vs ATP (500 microM) or ADP-beta-S
Design
Preclinical
Authors
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Supports ATP/ADP ratio as primary regulator of K+ channels in insulin-secreting cells; leaves open translation to human beta-cell function or therapy.
The physiological control of K+ channel opening in insulin-secreting cells is likely mediated by changes in the ATP/ADP ratio rather than ATP concentration alone.
Dunne et al. (1986) studied this question.
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