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December 1, 1993Journal of Biological ChemistryOpen Access

Arachidonic acid and endothelin potentiate Ca2+ transients in rat cardiac myocytes via inhibition of distinct K+ channels.

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Population

Suspensions of adult rat ventricular myocytes loaded with fura-2/AM and ventricular papillary muscle

Design

Preclinical

Authors

DDDerek S. DamronKent State UniversityDWDavid R. Van WagonerElectrophysiologyCMChristine S. MoravecHeart Failure & Transplant

Discussion

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Implication

No immediate clinical implications for inotropy; leaves open whether PKC effects on cardiac K+ channels translate to human disease models.

Structured PICO

P
Population
Suspensions of adult rat ventricular myocytes loaded with fura-2/AM and ventricular papillary muscle
I
Intervention
Arachidonic acid and endothelin (alone and in combination)
O
Outcome
Ca2+ transients evoked by extracellular ATP and K+ channel currentssurrogate

Arachidonic acid and endothelin modulate inotropic activity in cardiac muscle via protein kinase C-dependent inhibition of distinct K+ channels, prolonging action potential duration and increasing Ca2+ influx.

Cite This Study

Damron et al. (1993) studied this question.

synapsesocial.com/papers/6a6fbd05f44fa9f079dd37dahttps://doi.org/10.1016/s0021-9258(19)74254-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of the Cardiac Ryanodine Receptor by Protein Kinase-Dependent Phosphorylation11991 · 203 citations
  2. 2Ryanodine releases calcium from sarcoplasmic reticulum in calcium‐tolerant rat cardiac myocytes.1987 · 103 citations
  3. 3The mechanism of ryanodine action in rabbit ventricular muscle evaluated with Ca-selective microelectrodes and rapid cooling contractures1987 · 77 citations
  4. 4Alpha-adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes1991 · 80 citations
  5. 5Alpha 1-adrenergic agonists selectively suppress voltage-dependent K+ current in rat ventricular myocytes.1988 · 212 citations