April 30, 2009Journal of Cardiovascular Electrophysiology

Synergistic Effects of Inward Rectifier (IK1) and Pacemaker (If) Currents on the Induction of Bioengineered Cardiac Automaticity

View Full Paper

Ask AI

Bookmark

Population

Single left ventricular (LV) cardiomyocytes isolated from guinea pig hearts

Comparison

Transduction with recombinant adenoviruses… vs Single transduction

Design

Preclinical

Authors

YCYau-Chi ChanQueen Mary Hospital CSChung‐Wah SiuElectrophysiology YLYEE‐MAN LAUChinese University of Hong Kong

Discussion

Member takes

Implication

Animal cotransduction data support I(K1)-I(f) synergy; extends bioengineering rationale but leaves clinical pacemaker translation open.

Structured PICO

Population

Single left ventricular (LV) cardiomyocytes isolated from guinea pig hearts

Intervention

Transduction with recombinant adenoviruses Ad-CMV-GFP-IRES-HCN1-AAA and/or Ad-CGI-Kir2.1

Comparator

Single transduction (Ad-CGI-HCN1-AAA or Ad-CGI-Kir2.1 alone)

Outcome

Induction of automaticity (firing frequency)surrogate

An optimal level of I(K1) maintains a voltage range for I(f) to operate most effectively, demonstrating synergy in bioengineered cardiac automaticity.

Cite This Study

Chan et al. (2009) studied this question.

synapsesocial.com/papers/6a6fbd635d37378ac1dccd6a https://doi.org/10.1111/j.1540-8167.2009.01475.x

View Full Paper

Ask AI

Bookmark

Synergistic Effects of Inward Rectifier (IK1) and Pacemaker (If) Currents on the Induction of Bioengineered Cardiac Automaticity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Synergistic Effects of Inward Rectifier (IK1) and Pacemaker (If) Currents on the Induction of Bioengineered Cardiac Automaticity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider